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Post-transplant Long-term Complications

5. Substantiate your answer. A 56-year-old kidney transplant patient presented to you in the clinic 6 months after ABOI transplantation with severe headache and blurring of vision. He has excellent kidney function and currently on Tacrolimus-based triple immunosuppression. T1 MRI picture is shown below.
25
Feb
128

Explain the image finding What is the difference between T1 and T2-weighted images? What is your differential diagnosis? How would you manage this case?

Posted in: Post-transplant Long-term Complications , Week 6 ,
4. A 57-year-old CKD 5 called for cadaveric renal transplantation. He has been on the waiting list for 6 years. 212 mismatch, no DSA and negative FAXM. He was recently diagnosed with biopsy-proven BCC on the scalp waiting for excision (confirmed 2 days before this admission).
25
Feb
190

How do you manage this case? Will you proceed with the transplantation as planned?

Posted in: Post-transplant Long-term Complications , Week 6 ,
3. A 41-year-old man came forward to donate a kidney to his brother. 000 mismatch, excellent kidney function, no DSA. His GP reported that he had a positive Heaf test.
25
Feb
136

How would you proceed?

Posted in: Post-transplant Long-term Complications , Week 6 ,
2. What is the interaction of the anti-tuberculous drugs (Rifampicin and INH) with the following immunosuppression medications?
25
Feb
154

Tacrolimus Cyclosporine Sirolimus Azathioprine Mycophenolate Mofetil Prednisone

Posted in: Post-transplant Long-term Complications , Week 6 ,
1. A 47-year-old CKD 5 has kidney transplantation from his brother, 111 mismatch, and no DSAs. Excellent kidney function. One year later, he presented with a night fever of 39 C, productive cough, and weight loss. Imaging showed multiple shadows in both lungs.
25
Feb
188

How do you manage this case? Would your management differ if the disease was mild and affected one lung?

Posted in: Post-transplant Long-term Complications , Week 6 ,
III. Trimethoprim-Sulfamethoxazole (Bactrim) Dose Optimization in Pneumocystis jirovecii Pneumonia (PCP) Management: A Systematic Review
18
Feb
137

Please summarise this article. What is the level of evidence provided by this article? View / Download

Posted in: Post-transplant Long-term Complications , Week 5 ,
II. Drug Resistance in Pneumocystis jirovecii
18
Feb
124

Please summarise this article. What is the level of evidence provided by this article? View / Download

Posted in: Post-transplant Long-term Complications , Week 5 ,
I. Impact of Pneumocystis jirovecii pneumonia on kidney transplant outcome
18
Feb
168

Please summarise this article. What is the level of evidence provided by this article? View / Download

Posted in: Post-transplant Long-term Complications , Week 5 ,
5. A 48-year-old woman was admitted with epigastric pain and deterioration of kidney function 2 months after ABOi kidney transplantation. A routine infection screen and USS of her kidney were normal. USS of the liver and gall bladder was also reported normal. Anti-A IgG titre has risen from 1/8 to 1/512. CMV positive/CMV negative transplantation on Valganciclovir® 900 mg/daily. Kidney biopsy and C4d staining are shown below:
18
Feb
134

OGD and biopsy are shown below: Describe the finding. How do you manage the case?

Posted in: Post-transplant Long-term Complications , Week 5 ,
4. The picture below is for PCP (Pneumocystis pneumonia caused by Pneumocystis Jirovecii) diagnosed by lung biopsy
18
Feb
150

What are the modalities used in the diagnosis of this disease? What are their sensitivities and specificities? What is the place of lung biopsy in the diagnosis of PJP?

Posted in: Post-transplant Long-term Complications , Week 5 ,