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Post-transplant Long-term Complications

2. A 71-year-old male with hypertensive nephropathy received a kidney graft in February 2016. He had a history of colon adenocarcinoma in June 2019. His baseline Cr was 240–260 μmol/L. His immunosuppressive regimen included prednisolone 5 mg OD, tacrolimus (trough level was 6.4 ng/mL), and MMF 250 mg BD. He was also on calcium channel blockers and proton pump inhibitors. He presented in April 2020 with a dry cough with no other symptoms but stable vital signs. However, a chest X-ray revealed an infra-hilar consolidation on the right side.
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Mar
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Posted in: Post-transplant Long-term Complications , Week 9 ,
1. A 21-year-old female − who had a deceased donor kidney transplant in December 2019 presented on March 30 with a fever (39.2°C). She felt lethargic and generally unwell, with no respiratory symptoms. Clinical examination was unremarkable (apart from high temperature), and the chest X-ray was clear. Urine and blood cultures were negative. She is hypertensive and maintained on calcium channels and β-blockers. She was on prednisone 5 mg once daily (OD), tacrolimus 2 mg twice a day (BD), and mycophenolate mofetil 250 mg (BD).
18
Mar
130

What is the differential diagnosis? How would you manage this case?

Posted in: Post-transplant Long-term Complications , Week 9 ,
UPPER RESPIRATORY TRACT INFECTION
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Mar
32
Posted in: Post-transplant Long-term Complications , Week 9 ,
2. You were offered kidneys from a 56-year-old male DBD (donor after brain stem death) donor who suffered from SAH (grade 5) complicating cerebral aneurysm. His retrieval S Cr was 65 µmol/L. Virology was reported as follows: HBsAg negative, HBsAb negative, HBcAb negative, and both HBeAg and HBeAb are negative. HCV antibody and HCV PCR are positive. HIV is negative
12
Mar
121

Will you accept this DBD donor? If yes, how would you proceed?

Posted in: Post-transplant Long-term Complications , Week 8 ,
IV. UK Position Statement on the use of Organs from Hepatitis C Viraemic Donors and Increased Infectious Risk Donors in Hepatitis C Negative Recipient
10
Mar
82

Please summarise this article. View / Download

Posted in: Post-transplant Long-term Complications , Week 8 ,
III. Organ transplantation in persons with HIV
10
Mar
84

Please summarise this article. View / Download

Posted in: Post-transplant Long-term Complications , Week 8 ,
II. Hepatitis C Virus Treatment and Solid Organ Transplantation
10
Mar
93

Please summarise this article. View / Download

Posted in: Post-transplant Long-term Complications , Week 8 ,
I. Kidney & Pancreas Transplantation in Patients with HIV
10
Mar
87

Please summarise this article. View / Download

Posted in: Post-transplant Long-term Complications , Week 8 ,
6. A 41-year-old CKD patient on HD secondary to HIVAN (HIV-associated nephritis) came to see you in your clinic to discuss renal transplantation. His HCV PCR is positive but HBsAg negative.
10
Mar
94

Outline the workup required to prepare him for renal transplantation.

Posted in: Post-transplant Long-term Complications , Week 8 ,
5. A 35-year-old CKD patient on HD secondary to HIVAN (HIV-associated nephritis) came to see you in your clinic to discuss renal transplantation.
10
Mar
114

Please counsel this patient discussing the pros and cons of transplantation. Will you elaborate more on HIVAN? What are the chances of recurrence of HIVAN post-transplantation?

Posted in: Post-transplant Long-term Complications , Week 8 ,
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