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Week 9

IV. BK virus infection in renal transplant recipients: an overview
18
Mar
137

Please summarise this article. What is the level of evidence provided by this article? View / Download

Posted in: Post-transplant Long-term Complications , Week 9 ,
III. Respiratory Viruses in Solid Organ Transplant Recipients
18
Mar
82

Please summarise this article. What is the level of evidence provided by this article? View / Download

Posted in: Post-transplant Long-term Complications , Week 9 ,
II. Dexamethasone in Hospitalized Patients with Covid-19
18
Mar
94

Please do your own search and summarise the outcome of the different arms of the recovery trial. Please summarise this article. What is the level of evidence provided by this article? View / Download

Posted in: Post-transplant Long-term Complications , Week 9 ,
I. COVID-19 in Renal Transplant Recipients: Case Series and a Brief Review of Current Evidence
18
Mar
126

Please summarise this article. What is the level of evidence provided by this article? What is meant by the impact factor of a journal? View / Download

Posted in: Post-transplant Long-term Complications , Week 9 ,
5. An a-61-year-old female patient presented with a 3-month history of multiple sinuses in the right side of the face (see below) without fever 7 months after receiving a kidney transplant from his 32-year-old son. She is on Tacrolimus-based triple immunosuppression with excellent graft function.
18
Mar
91

What is your differential diagnosis? Is it a common site for this form of infection? Outline the principle of diagnosis and treatment of this condition regarding immunosuppressed patients!

Posted in: Post-transplant Long-term Complications , Week 9 ,
4. A 61-year-old man was admitted with fever (38 °C) and malaise 2 months after cadaveric transplantation, 000 mismatch on Tacrolimus (trough 9 ng/ml) and prednisolone 15 mg/day. CMV is positive to CMV negative recipient. Oxygen saturation was reported to be 95% on air. Quantitative CMV PCR reported 5.52 log 10 copies/ml. The patient has not responded to oral valganciclovir 900 mg twice daily.
18
Mar
93

What is your management strategy? What are the other tests to diagnose and monitor CMV? Assume this patient is asymptomatic; what is your cut-off level to treat asymptomatic CMV viraemia (pre-emptive therapy)? What is the duration of pre-emptive treatment? What is the relation between the viral load and the development of CMV disease?

Posted in: Post-transplant Long-term Complications , Week 9 ,
3. A 50-year-old male with a history of Wegner’s granulomatosis received a live donor kidney transplant in February 2020. He presented on April 3 with a productive cough and tested positive for SARS-CoV-2 RNA despite unremarkable clinical examination. The chest X-ray was clear, and kidney function tests were stable. His immunosuppressive drugs were prednisolone 5 mg OD, tacrolimus (trough level was 13.4 ng/mL), and MMF 500 mg BD.
18
Mar
106

How would you manage this case? Substantiate your answer

Posted in: Post-transplant Long-term Complications , Week 9 ,
2. A 71-year-old male with hypertensive nephropathy received a kidney graft in February 2016. He had a history of colon adenocarcinoma in June 2019. His baseline Cr was 240–260 μmol/L. His immunosuppressive regimen included prednisolone 5 mg OD, tacrolimus (trough level was 6.4 ng/mL), and MMF 250 mg BD. He was also on calcium channel blockers and proton pump inhibitors. He presented in April 2020 with a dry cough with no other symptoms but stable vital signs. However, a chest X-ray revealed an infra-hilar consolidation on the right side.
18
Mar
100
Posted in: Post-transplant Long-term Complications , Week 9 ,
1. A 21-year-old female − who had a deceased donor kidney transplant in December 2019 presented on March 30 with a fever (39.2°C). She felt lethargic and generally unwell, with no respiratory symptoms. Clinical examination was unremarkable (apart from high temperature), and the chest X-ray was clear. Urine and blood cultures were negative. She is hypertensive and maintained on calcium channels and β-blockers. She was on prednisone 5 mg once daily (OD), tacrolimus 2 mg twice a day (BD), and mycophenolate mofetil 250 mg (BD).
18
Mar
130

What is the differential diagnosis? How would you manage this case?

Posted in: Post-transplant Long-term Complications , Week 9 ,
UPPER RESPIRATORY TRACT INFECTION
18
Mar
32
Posted in: Post-transplant Long-term Complications , Week 9 ,
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