The patient continued to have improvement of her fatigue. A significant improvement in her depressive illness was noted using a patient-rated Hamilton Scale for depression (HAM-D).
Follow-up lab tests results showed the following:
Test
Value
S. Creatinine
0.7 mg/dL
S. Corrected CalciumÂ
8.7Â mg/dL
S. Phosphorus
3.6 mg/dL
25(OH) vit D
43 ng/mL
iPTH
38 pg/ml
Â
Interpret the above follow-up lab tests.
Enumerate the complications of severe vit D deficiency.
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Amna Kununa
Interpret the above follow-up lab tests.
Normalization of vit D level as well as calcium and PTH
Enumerate the complications of severe vit D deficiency.
Hypocalcemia and hypophosphatemia secondary to reduced intestinal absorption of calcium and phosphorus.
SHPT as a result of hypocalcemia
Phosphaturia due to reduce GI absorption and SHPT.
Demineralization of bones, and when prolonged, osteomalacia
Labs showed normalization of vitamin D, hence hypocalcemia and SHPT improved.
complications of vitamin D deficiency: hypocalcemia, impaired bone mineralization- osteomalacia-, SHPT- hyper dynamic bone disease-, increase risk of cancer, insulin resistance, uncontrolled BP, hypertriglyceridemia, anemia, endothelial dysfunction, immune-paresis, increase cardiovascular and all cause mortality,
correction of vitamin D deficiency and normalisation of calcium
complication of vitamin d deficiency
1/tiredness/muscle ache
2 low calcium and increased PTH osteomalacia ,fractures in elderly
1- improved lab results of calcium and vit D as compared to previous results
2- hypocalcemia with its sequelae
-hypophosphatemia
-rickets in children
-osteomalacia in adults
Vitamin D level improved, serum calcium and PTH levels returned to normal. The patient’s symptoms improved
Enumerate the complications of severe vit D deficiency.
The most serious complications of vitamin D deficiency are low blood calcium (hypocalcemia), low blood phosphate (hypophosphatemia), rickets (softening of the bones during childhood), and osteomalacia (softening of the bones in adults).
Elevated parathyroid hormone (which accelerates bone resorption), an increased risk of falls, and possibly fractures, all of which can seriously affect a person’s quality of life.
Vitamin D deficiency has been linked to depression, especially in older adults
1. Interpret the above follow-up lab tests Normal levels regarding the previous laboratory investigations as vitamin D level improved, serum calcium and PTH levels returned to normal. Beside the normalization of these labs, the patient’s symptoms improved which reflects good response to his management plan.
2. Enumerate the complications of severe vit D deficiency.
Chronic hypocalcemia and hyperparathyroidism which can induce osteoporosis.
Increase risk of falls and fractures especially in the elderly population.
Symptoms associated with secondary hyperparathyroidism include bone pain, arthralgias, myalgias, fatigue, muscle twitching (fasciculations), and weakness. Fragility fractures may result from chronic vitamin D deficiency leading to osteoporosis.
Interpret the above follow-up lab tests. Calcium, PO4, and vitamin D levels back to normal ranges. Enumerate the complications of severe vit D deficiency. Low S, ca, ph Rickets Osteomalacia Fatigue. Sleep problems Bone pain or achiness. Depression, or feelings of sadness. Hair loss. Muscle weakness. Loss of appetite.
1-Interpret the above follow-up lab tests.
there is normalization of her Lab test with replenish of vitamin D level. 2-Enumerate the complications of severe vit D deficiency.
hypocalcemia and hypophosphatemia
muscle pain and bone and joint pain
depressive mood and poor cognitive function
obesity
DM
HT
poor wound healing
increase infection
increase cancers
1- interpretation of lab normalization of her lab and restore vit D level .
2-Enumerate the complications of severe vit D deficiency bone pains muscle weakness with myalgia, back pain and arthralgias.arrhythmia and low cardiac contractility.
predispose to inflammation, auto-immune diseases, and even malignancies.
depression and poor psychological status
NORMAILSED VIT D AND OTHER LAB TESTS , MANY COMPLICATIONS RELATED TO SEVERE VIT D DEF INCLUDING MODE CHANGE , FATIGUE , TIREDNESS , MUSCLE PAIN , METABLOC SYNDROME DIABETIS , CANSER , VASCULLAR , KIDNEY AND OTHER SITES
Hypovitaminosis D is associated with cardiovascular disease, the metabolic syndrome, type 2 diabetes mellitus, cancer as well as with increased mortality. Further, Vitamin D deficiency is related to depression and impaired cognitive function. Increasing age and elevated body fat mass contribute to an increased risk of Vitamin D deficiency. A mild lack of vitamin D may not cause symptoms but can cause tiredness and general aches and pains. A more severe lack can cause serious problems such as rickets (in children) and osteomalacia in adults).
1.normal kidney function, vitamin D level, CA
2. Bone pain and fracture, Ricket and osteomalacia, osteoporosis
Anemia
Innate and adaptive dysfunction and liability for infection
Cardio-vascular dysfunction
Muscle pain and weakness
sufficient amount of vitamin D (>30 ng/ml), normal labs.
Complication of severe vitamin D Deficiency are increased risk of fall and bone/Hip fracture, osteoporosis or osteomalacia, depression, hypocalcemia, hypophosphatemia, immune system dysfunction, endothelial dysfunction, muscle weakness and fatigue, increased risk of cardiovascular events, congnitive decline. increased risk of infection.
The metabolic picture of the patients improved. Hypocalcemia, low vit. d and low phosphate are improved.
Vitamin d deficiency leads to osteomalacia and rickets. Hypocalcemia and hypophosphatemia will lead to fatigue and decreased energy. Muscle weakness and loss of appetite. May have compromisation in the immune system.
The patient all bochemical data improved with good level of vit d level
Enumerate the complications of severe vit D deficiency.
severe vit d deficiency can cause hypocalcemia and hypophophateamia. along with rickets in children and osteomalacia in adult.
iN Vit D WE NEED TO KNOW THE level of vit D
it is categorize to Vit D insufficiency which is Vit D level of 30 to 50 mol/l ,Vit D sufficiency is of more than 50nmol/l and Vit D deficiency is of less than 30nmol/l .
Calcium, PO4, and vitamin D levels have returned to normal ranges.
Enumerate the complications of severe vit D deficiency.
blood calcium (hypocalcemia), low blood phosphate (hypophosphatemia), rickets (softening of the bones during childhood), and osteomalacia (softening of the bones in adults)
Fatigue.
Not sleeping well.
Bone pain or achiness.
depression, or feelings of sadness.
Hair loss.
Muscle weakness.
Loss of appetite.
The clinical picture is compatible with the lab findings i.e, her Ca & vitamin D levels are now within normal ranges
2.Enumerate the complications of severe vit D deficiency
-Cardiovascular mortality
-All cause mortality
-Skeletal & Extra-skeletal manifestations:
A.Skeletal
Bone pain, rickets & osteomalacia
Fractures
B.Extra-skeletal
Multi-system disease .,e.g anemia, hypertension,weakness, fatigue, depression,seizures, headaches and poor quality of life
2. Enumerate the complications of severe vit D deficiency.
Bone complications such as Osteomalacia, Rickets, bone pain, muscle weakness, fractures and tetany.
Lab: hypocalcemia-hypophosphatemia-hyperparathyroidism mood disturbances such as depression low immunity
Excellent improvement of the pt. the vit. d is essential as mentioned its deficiency lead to hypocalcemia and hypophosphatemia and their complication also affect on nervous system and musculoskeletal system and immune system
Interpret the above follow-up lab tests.
Normalization of vit D level as well as calcium and PTH
Enumerate the complications of severe vit D deficiency.
Correct vit d level ca and PTH
2nd hyper pth. Ostemaici and depression
Improve vitaminD level
2- osteoporosis, osteomalacia , fracture
depression
rickets in pediatric
correction of vitamin D deficiency and normalisation of calcium
complication of vitamin d deficiency
1/tiredness/muscle ache
2 low calcium and increased PTH osteomalacia ,fractures in elderly
Interpret the above follow-up lab tests.
patients lab investigation improved
compare to previous laboratory
hypocalcemia , hypophophotamia . softening of bones
. ostemialies
1- improved lab results of calcium and vit D as compared to previous results
2- hypocalcemia with its sequelae
-hypophosphatemia
-rickets in children
-osteomalacia in adults
Vitamin D level improved, serum calcium and PTH levels returned to normal.
The patient’s symptoms improved
1. Interpret the above follow-up lab tests
Normal levels regarding the previous laboratory investigations as vitamin D level improved, serum calcium and PTH levels returned to normal. Beside the normalization of these labs, the patient’s symptoms improved which reflects good response to his management plan.
2. Enumerate the complications of severe vit D deficiency.
Interpret the above follow-up lab tests.
Calcium, PO4, and vitamin D levels back to normal ranges.
Enumerate the complications of severe vit D deficiency.
Low S, ca, ph
Rickets
Osteomalacia
Fatigue.
Sleep problems
Bone pain or achiness.
Depression, or feelings of sadness.
Hair loss.
Muscle weakness.
Loss of appetite.
1-Interpret the above follow-up lab tests.
there is normalization of her Lab test with replenish of vitamin D level.
2-Enumerate the complications of severe vit D deficiency.
hypocalcemia and hypophosphatemia
muscle pain and bone and joint pain
depressive mood and poor cognitive function
obesity
DM
HT
poor wound healing
increase infection
increase cancers
1- interpretation of lab normalization of her lab and restore vit D level .
2-Enumerate the complications of severe vit D deficiency bone pains muscle weakness with myalgia, back pain and arthralgias.arrhythmia and low cardiac contractility.
predispose to inflammation, auto-immune diseases, and even malignancies.
depression and poor psychological status
Interpret the above follow-up lab tests.
Enumerate the complications of severe vit D deficiency.
NORMAILSED VIT D AND OTHER LAB TESTS , MANY COMPLICATIONS RELATED TO SEVERE VIT D DEF INCLUDING MODE CHANGE , FATIGUE , TIREDNESS , MUSCLE PAIN , METABLOC SYNDROME DIABETIS , CANSER , VASCULLAR , KIDNEY AND OTHER SITES
The new lab result shows
The patient restores his vitamin D normal level.
The complication of vitD deficiency
2.Infection.
3.Cancer
4. CV
5. DM.
6. Obesity.
7. Bone and muscles
1.normal kidney function, vitamin D level, CA
2. Bone pain and fracture, Ricket and osteomalacia, osteoporosis
Anemia
Innate and adaptive dysfunction and liability for infection
Cardio-vascular dysfunction
Muscle pain and weakness
The metabolic picture of the patients improved. Hypocalcemia, low vit. d and low phosphate are improved.
Vitamin d deficiency leads to osteomalacia and rickets. Hypocalcemia and hypophosphatemia will lead to fatigue and decreased energy. Muscle weakness and loss of appetite. May have compromisation in the immune system.
The patient all bochemical data improved with good level of vit d level
severe vit d deficiency can cause hypocalcemia and hypophophateamia. along with rickets in children and osteomalacia in adult.
iN Vit D WE NEED TO KNOW THE level of vit D
it is categorize to Vit D insufficiency which is Vit D level of 30 to 50 mol/l ,Vit D sufficiency is of more than 50nmol/l and Vit D deficiency is of less than 30nmol/l .
Calcium, PO4, and vitamin D levels have returned to normal ranges.
blood calcium (hypocalcemia), low blood phosphate (hypophosphatemia), rickets (softening of the bones during childhood), and osteomalacia (softening of the bones in adults)
Fatigue.
Not sleeping well.
Bone pain or achiness.
depression, or feelings of sadness.
Hair loss.
Muscle weakness.
Loss of appetite.
1.Interpret the above follow-up lab tests.
2.Enumerate the complications of severe vit D deficiency
-Cardiovascular mortality
-All cause mortality
-Skeletal & Extra-skeletal manifestations:
A.Skeletal
B.Extra-skeletal
1. Interpret the above follow-up lab tests.
clinically improved
2. Enumerate the complications of severe vit D deficiency.
Bone complications such as Osteomalacia, Rickets, bone pain, muscle weakness, fractures and tetany.
Lab: hypocalcemia-hypophosphatemia-hyperparathyroidism
mood disturbances such as depression
low immunity
interpret the above follow-up lab tests
clinically
-case improvement
laboratory
normal serum calcium, phosphorus PTH and ,creatinine
.Enumerate the complications of severe vit D deficiency.
1-improvement of the patient clinically and laboratory
normal calcium ,po4 ,PTH ,VIT D
complication of VIT D deficiency
hypocalcemia
hypophosphatemia
osteomalacia
rickets in children
Excellent improvement of the pt.
the vit. d is essential as mentioned
its deficiency lead to hypocalcemia and hypophosphatemia and their complication
also affect on nervous system and musculoskeletal system and immune system
interpret the above follow-up lab tests.
Enumerate the complications of severe vit D deficiency.