Scenario 3 - Part 3:

Part II: three months later

The patient continued to have improvement of her fatigue.  A significant improvement in her depressive illness was noted using a patient-rated Hamilton Scale for depression (HAM-D).

Follow-up lab tests results showed the following:

Test

Value

S. Creatinine

0.7 mg/dL

S. Corrected Calcium 

8.7 mg/dL

S. Phosphorus

3.6 mg/dL

25(OH) vit D

43 ng/mL

iPTH

38 pg/ml

 

  1. Interpret the above follow-up lab tests.
  2. Enumerate the complications of severe vit D deficiency.

30 Comments

  • Amna Kununa


    Interpret the above follow-up lab tests.

    Normalization of vit D level as well as calcium and PTH

    Enumerate the complications of severe vit D deficiency.

    • Hypocalcemia and hypophosphatemia secondary to reduced intestinal absorption of calcium and phosphorus.
    • SHPT as a result of hypocalcemia
    • Phosphaturia due to reduce GI absorption and SHPT.
    • Demineralization of bones, and when prolonged, osteomalacia
  • Marwa Alm


    • Labs showed normalization of vitamin D, hence hypocalcemia and SHPT improved.
    • complications of vitamin D deficiency: hypocalcemia, impaired bone mineralization- osteomalacia-, SHPT- hyper dynamic bone disease-, increase risk of cancer, insulin resistance, uncontrolled BP, hypertriglyceridemia, anemia, endothelial dysfunction, immune-paresis, increase cardiovascular and all cause mortality,
  • Khaldon Rashed Ahmed Moqbil


    Correct vit d level ca and PTH
    2nd hyper pth. Ostemaici and depression

  • Asma Aljaberi


    1. Interpret the above follow-up lab tests.
    • Vit D level is replenished, which normalizes Ca and PTH levels.
    1. Enumerate the complications of severe vit D deficiency.
    • Severe vit D deficiency can cause osteomalacia.
    • Prolonged period of secondary hyperparathyroidism can lead to osteoporosis.
    • Severe depression
  • Areij Alotaibi


    Improve vitaminD level

    2- osteoporosis, osteomalacia , fracture
    depression
    rickets in pediatric

  • Muhammad Soobadar


    correction of vitamin D deficiency and normalisation of calcium
    complication of vitamin d deficiency
    1/tiredness/muscle ache
    2 low calcium and increased PTH osteomalacia ,fractures in elderly

  • Mohamed Abdulahi Hassan


    Interpret the above follow-up lab tests.
    patients lab investigation improved
    compare to previous laboratory

    1. Enumerate the complications of severe vit D deficiency.

    hypocalcemia , hypophophotamia . softening of bones

    . ostemialies

  • Mark Nagy Zaki Amin Mark


    1- improved lab results of calcium and vit D as compared to previous results
    2- hypocalcemia with its sequelae
    -hypophosphatemia
    -rickets in children
    -osteomalacia in adults

  • Rania Mahmoud


    1. Interpret the above follow-up lab tests.

    Vitamin D level improved, serum calcium and PTH levels returned to normal.
    The patient’s symptoms improved

    1. Enumerate the complications of severe vit D deficiency.
    • The most serious complications of vitamin D deficiency are low blood calcium (hypocalcemia), low blood phosphate (hypophosphatemia), rickets (softening of the bones during childhood), and osteomalacia (softening of the bones in adults). 
    • Elevated parathyroid hormone (which accelerates bone resorption), an increased risk of falls, and possibly fractures, all of which can seriously affect a person’s quality of life.
    • Vitamin D deficiency has been linked to depression, especially in older adults 
  • Rabab Elrefaey


    1. Interpret the above follow-up lab tests
    Normal levels regarding the previous laboratory investigations as vitamin D level improved, serum calcium and PTH levels returned to normal. Beside the normalization of these labs, the patient’s symptoms improved which reflects good response to his management plan.

    2. Enumerate the complications of severe vit D deficiency.

    • Chronic hypocalcemia and hyperparathyroidism which can induce osteoporosis.
    • Increase risk of falls and fractures especially in the elderly population. 
    • Symptoms associated with secondary hyperparathyroidism include bone pain, arthralgias, myalgias, fatigue, muscle twitching (fasciculations), and weakness. Fragility fractures may result from chronic vitamin D deficiency leading to osteoporosis.
    • Mood changes, like depression
  • Mahmoud Elsheikh


    Interpret the above follow-up lab tests.
    Calcium, PO4, and vitamin D levels back to normal ranges.
    Enumerate the complications of severe vit D deficiency.
    Low S, ca, ph
    Rickets
    Osteomalacia
    Fatigue.
    Sleep problems
    Bone pain or achiness.
    Depression, or feelings of sadness.
    Hair loss.
    Muscle weakness.
    Loss of appetite.

  • Asmaa Salih KHUDHUR


    1-Interpret the above follow-up lab tests.
    there is normalization of her Lab test with replenish of vitamin D level.
    2-Enumerate the complications of severe vit D deficiency.
    hypocalcemia and hypophosphatemia
    muscle pain and bone and joint pain
    depressive mood and poor cognitive function
    obesity
    DM
    HT
    poor wound healing
    increase infection
    increase cancers

  • Rabab ALaa Eldin keshk Rabab


    1- interpretation of lab normalization of her lab and restore vit D level .
    2-Enumerate the complications of severe vit D deficiency bone pains muscle weakness with myalgia, back pain and arthralgias.arrhythmia and low cardiac contractility.
    predispose to inflammation, auto-immune diseases, and even malignancies.
    depression and poor psychological status

  • Riaan Flooks


    1. Normal biochemistry with repleted Vit D levels
    2. Hypocalcemia, Hypophosphatemia and Rickets
  • Ahmed Altalawy


    Interpret the above follow-up lab tests.

    • normal serum creatinine, calcium, phosphorus, and PTH.
    • repleted Vit. D stores.

    Enumerate the complications of severe vit D deficiency.

    • bone pains.
    • muscle weakness with myalgia, back pain and arthralgias.
    • arrhythmia and low cardiac contractility.
    • predispose to inflammation, auto-immune diseases, and even malignancies.
    • depression and poor psychological status
  • Abdulrahman Almutawakel


    NORMAILSED VIT D AND OTHER LAB TESTS , MANY COMPLICATIONS RELATED TO SEVERE VIT D DEF INCLUDING MODE CHANGE , FATIGUE , TIREDNESS , MUSCLE PAIN , METABLOC SYNDROME DIABETIS , CANSER , VASCULLAR , KIDNEY AND OTHER SITES

  • HASSAN ALYAMMAHI


    1. Patient has now normal profile of Ca, PO4, VitD
    2. Fatigue, Susceptibility to Infection, Osteoporosis / Osteomalacia, Muscle pain and weakness, Depression, Cognitive dysfunction, Slow wound healing,? inflammatory bowl diseases, Insulin resistance, CVD
  • Hagar Ali


    1. normal lab results
    2. Hypovitaminosis D is associated with cardiovascular disease, the metabolic syndrome, type 2 diabetes mellitus, cancer as well as with increased mortality. Further, Vitamin D deficiency is related to depression and impaired cognitive function. Increasing age and elevated body fat mass contribute to an increased risk of Vitamin D deficiency. A mild lack of vitamin D may not cause symptoms but can cause tiredness and general aches and pains. A more severe lack can cause serious problems such as rickets (in children) and osteomalacia in adults).  
  • KAMAL ELGORASHI


    The new lab result shows
    The patient restores his vitamin D normal level.
    The complication of vitD deficiency

    1. Psychiatric
    • Depression.
    • Pseophrenia.

    2.Infection.
    3.Cancer

    • Breast.
    • Colon.
    • Prostate.
    • Others.

    4. CV

    • LFH.
    • HTN.
    • CAD.

    5. DM.
    6. Obesity.
    7. Bone and muscles

    • Fractures (osteoporosis, osteomalacia, arthritis, bone pain).

  • Israa Hammoodi


    1.normal kidney function, vitamin D level, CA
    2. Bone pain and fracture, Ricket and osteomalacia, osteoporosis
    Anemia
    Innate and adaptive dysfunction and liability for infection
    Cardio-vascular dysfunction
    Muscle pain and weakness

  • Nour Al Natout


    1. sufficient amount of vitamin D (>30 ng/ml), normal labs.
    2. Complication of severe vitamin D Deficiency are increased risk of fall and bone/Hip fracture, osteoporosis or osteomalacia, depression, hypocalcemia, hypophosphatemia, immune system dysfunction, endothelial dysfunction, muscle weakness and fatigue, increased risk of cardiovascular events, congnitive decline. increased risk of infection.
  • Mahmud ISLAM


    The metabolic picture of the patients improved. Hypocalcemia, low vit. d and low phosphate are improved.
    Vitamin d deficiency leads to osteomalacia and rickets. Hypocalcemia and hypophosphatemia will lead to fatigue and decreased energy. Muscle weakness and loss of appetite. May have compromisation in the immune system.

  • Rihab Elidrisi


    1. Interpret the above follow-up lab tests.

    The patient all bochemical data improved with good level of vit d level

    1. Enumerate the complications of severe vit D deficiency.

    severe vit d deficiency can cause hypocalcemia and hypophophateamia. along with rickets in children and osteomalacia in adult.

    iN Vit D WE NEED TO KNOW THE level of vit D
    it is categorize to Vit D insufficiency which is Vit D level of 30 to 50 mol/l ,Vit D sufficiency is of more than 50nmol/l and Vit D deficiency is of less than 30nmol/l .

  • Weam El Nazer


    1. Interpret the above follow-up lab tests.

    Calcium, PO4, and vitamin D levels have returned to normal ranges.

    1. Enumerate the complications of severe vit D deficiency.

     blood calcium (hypocalcemia), low blood phosphate (hypophosphatemia), rickets (softening of the bones during childhood), and osteomalacia (softening of the bones in adults)
    Fatigue.
    Not sleeping well.
    Bone pain or achiness.
    depression, or feelings of sadness.
    Hair loss.
    Muscle weakness.
    Loss of appetite.

  • Ben Lomatayo


    1.Interpret the above follow-up lab tests.

    • The clinical picture is compatible with the lab findings i.e, her Ca & vitamin D levels are now within normal ranges

    2.Enumerate the complications of severe vit D deficiency
    -Cardiovascular mortality
    -All cause mortality
    -Skeletal & Extra-skeletal manifestations:
    A.Skeletal

    • Bone pain, rickets & osteomalacia
    • Fractures

    B.Extra-skeletal

    • Multi-system disease .,e.g anemia, hypertension,weakness, fatigue, depression,seizures, headaches and poor quality of life
  • MOHAMMED HAJI HASSAN


    1. Interpret the above follow-up lab tests.

    clinically improved

    2. Enumerate the complications of severe vit D deficiency.

    Bone complications such as Osteomalacia, Rickets, bone pain, muscle weakness, fractures and tetany. 
    Lab: hypocalcemia-hypophosphatemia-hyperparathyroidism
    mood disturbances such as depression
    low immunity

  • Ashraf Ahmed Mahmoud


    interpret the above follow-up lab tests

    clinically

    -case improvement

    laboratory
    normal serum calcium, phosphorus PTH and ,creatinine

    .Enumerate the complications of severe vit D deficiency.

    • low blood calcium, low blood phosphate
    • Softening of the bones
    • Muscle weakness
    • Fatigue
    • Cardiovascular disease
    • Asthma
    • Osteomalacia and.rickets
    • depression.
  • Emad mohamed mokbel Salem


    1-improvement of the patient clinically and laboratory
    normal calcium ,po4 ,PTH ,VIT D

    complication of VIT D deficiency
    hypocalcemia
    hypophosphatemia
    osteomalacia
    rickets in children

  • Elsayed Ghorab


    Excellent improvement of the pt.
    the vit. d is essential as mentioned
    its deficiency lead to hypocalcemia and hypophosphatemia and their complication
    also affect on nervous system and musculoskeletal system and immune system

  • Ibrahim Omar


    interpret the above follow-up lab tests.

    • normal serum creatinine, calcium, phosphorus, and PTH.
    • repleted Vit. D stores.

    Enumerate the complications of severe vit D deficiency.

    • bone pains.
    • muscle weakness with myalgia, back pain and arthralgias.
    • arrhythmia and low cardiac contractility.
    • predispose to inflammation, auto-immune diseases, and even malignancies.
    • depression and poor psychological status

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