Do you think the relationship between serum Mg and bone health and mortality is linear or U-shaped? Explain.
18 Comments
Muhammad Soobadar
The relationshio between serum magnesium and bone health/mortality is U Shaped. It means too low and too high level can cause mortality and need to aim along certain range as per observational studies on HD patient and large Japanes Cohort Study
This is supported by the evidence from a large Japanese cohort study reports a U-shaped curve for this association, as a blood Mg2þ concentration >1.27 mmol/L was associated with increased cardiovascular mortality. A blood Mg concentration between 1.14 and 1.27 mmol/L may be optimal and maintaining blood Mg2þ concentrations in this range in CKD and dialysis patients might be of importance
The relationship was found as U-shaped, not linear.
The Japanese cohort study showed that higher levels of magnesium (>1.27 mmol/L) could be associated with increased mortality as well.< 0.7 mmol/L is also known to increase cardiovascular mortality.
Observational studies in large groups of dialysis patients reported that a higher serum Mg2þ concentration is associated with a reduced risk of developing vascular calcification .Dialysis patients with a Mg2þ concentration <1.14mmol/L showed significantly more risk for mortality . In other studies, blood Mg2þ concentrations <1.23mmol/L , 1.15mmol/L and 1.21mmol/L were associated with increased cardiovascular and all-cause mortality in dialysis patients. Of note, these concentrations are all above the reference value for serumMg2þ. This suggests that supranormal Mg2þ concentrations beneficially impact survival rate in CKD. Importantly, a large Japanese cohort study reports a U-shaped curve for this association, as a blood Mg2þ concentration >1.27mmol/L was associated with increased cardiovascular mortality. Together, these observational studies suggest that a blood Mg2þ concentration between 1.14 and 1.27mmol/L may be optimal and maintaining blood Mg2þ concentrations in this range in CKD and dialysis patients might be of importance.
Do you think the relationship between serum Mg and bone health and mortality is linear or U-shaped? Explain.
Hypomagnesaemia (serum Mg2þ concentration <0.7 mmol/L) is a well-known risk factor for cardiovascular disease, events and mortality in the patients with higher baseline cardiovascular risk and in patients with dialysis-dependent CKD
This is supported by the evidence froma large Japanese cohort study reports a U-shaped curve for this association, as a blood Mg2þ concentration >1.27 mmol/L was associated with increased cardiovascular mortality. A blood Mg concentration between 1.14 and 1.27 mmol/L may be optimal and maintaining blood Mg2þ concentrations in this range in CKD and dialysis patients might be of importance
it’s a U shape relation, with hypomagnesemia (<0.7mmol) associated with negative outcome and hypermagnesemia (>1.27 mmol) associated with negative outcome
Hypomagnesaemia (Mg < 0.7 mmol/l) is a risk factor for cardiovascular disease, events & mortality in those with cardiovascular risk and dialysis patients.
The is supported by the evidence from a Japanese cohort study; they demonstrated that Mg > 1.27 mmol/l was associated with with increased cardiovascular mortality.
Hypomagnesaemia (serum Mg concentration <0.7mmol/L) is a well-known risk factor for cardiovascular disease, events and mortality in the patients with higher base- line cardiovascular risk and in patients with dialysis-dependent CKD .Besides its blood concentrations, low dietary Mg intake is also associated with all-cause mortality, risk of stroke, heart failure and diabetes mellitus type 2 in the general population .Lower blood Mg concentration is associated with an increased risk of death from heart failure and coronary heart disease, even at concentrations (0.7–0.8 mmol/L) that fall within the reference range for serum Mg ,which is typically between 0.7 and 1.0 mmol/L .
Observational studies in large groups of dialysis patients reported that a higher serum Mg concentration is associated with a reduced risk of developing vascular calcification .Dialysis patients with a Mg concentration <1.14mmol/L showed significantly more risk for mortality .In other studies, blood Mg concentrations <1.23 mmol/L ,1.15 mmol/L and 1.21 mmol/L were associated with increased cardiovascular and all-cause mortality in dialysis patients. Of note, these concentrations are all above the reference value for serum Mg .This suggests that supranormal Mg concentrations beneficially impact survival rate in CKD.
as a blood Mg concentration >1.27 mmol/L was associated with increased cardiovascular mortality , a large Japanese cohort study reports a U-shaped curve for this association.
Together, these observational studies suggest that a blood Mg concentration between 1.14 and 1.27 mmol/L may be optimal and maintaining blood Mg con- centrations in this range in CKD and dialysis patients might be of importance.
So the relationship between serum Mg and bone health and mortality is U-shaped.
Magnesium is important for many processes in the body. It is needed for muscles and nerves to work properly, to keep blood sugar and blood pressure at the right level, and to make protein, bone, and DNA.
hypomagnesemia was associated with increased cardiovascular mortality.
so . the relationship between serum Mg and bone health and mortality is U-shaped
The relation between bone health and serum mg and mortality is u shaped.
The explanation from a Japanese cohort study; they demonstrated that Mg > 1.27 mmol/l was associated with with increased cardiovascular mortality.
According to this study , Mg in the range of 1.14 to 1.27 mmol/l may be optimal but it has to be individualized so must maintain serum mg with in normal level and avoid hypomagnesemia and hypermagnisima
Income studies, blood Mg concentrations<1.23 mmol/l, 1.15 mmol/L and 1.21 mmol/L were associated with increased cardiovascular and all-cause mortality in dialysis patients.
Of note, these concentrations are all above the reference value for serum Mg. This suggests that supranormal Mg concentrations beneficially impact survival rate in CKD. Importantly, a large Japanese cohort study reports a U-shaped curve for this association, as a blood Mg concentration >1.27 mmol/L was associated with increased cardiovas- ocular mortality.
Together, these observational studies suggest that a blood Mg concentration between 1.14 and 1.27 mmol/L may be optimal and maintaining blood Mg concentrations in this range in CKD and dialysis patients might be of significance.
the relationship is u shaped high Mg level more than 1.27mmol/l was assosciated with hihg mortality while low Mg levels between 1.1-1.27 were optimal, serum Mg less than 0.7 is a well known risk factor of CVS disease
the relationship between serum Mg and bone health and mortality is U-shaped:
Studies have shown that there is an inverse correlation between serum Mg2+ levels and the risk of cardiovascular mortality, particularly among dialysis patients. Low levels of Mg2+ have been associated with higher rates of all-cause and cardiovascular mortality in these patients.
However, some research has suggested that higher than normal levels of Mg2+ could potentially be beneficial for individuals with CKD and undergoing dialysis.
Nonetheless, more research is necessary to establish the optimal range of serum Mg2+ values for these patients. Nevertheless, based on the existing evidence, it is advisable for CKD and dialysis patients to maintain their serum Mg2+ levels within the range of 1.14-1.27 mmol/L.
Mg deficiency in animal models results in less flexible bone as a result of brittle and tighter hydroxyapatite crystals.
A recent study showed that mild hypomagnesemia is associated with a lower risk of bone fracture in late-stage CKD patients.
High Mg level associated with compromisation of bone mineralization.
Mortality
As low Mg level is associated with adverse effects regarding vascular calcification, so advised to maintain Mg serum level at an optimum level so to reduce the level of vascular calcification and hence cardiovascular mortality.
In reverse, a Japanese cohort study shows that optimization of Mg level (as reported by the U-shape curve), to >1.27 mmol/l is associated with increased cardiovascular mortality.
So Mg level to be kept within the normal range is vital to reduce the risk of vascular calcification and hence mortality.
Bone considered the body Mg store, because 60%of total body body Mg is in the bone where it is embedded in the surface of the hydroxyapatite crystal.
When there is hypoMagnesemia the hydroxyapatite grow tighter and brittle and less flexible and more prone to fracture.
The Mg increase both osteoblastogenesis and osteoclastogenesis in vitro.
Many studies show that very high level of Blood Mg in late stages CKD patient can affect bone mineralization as Mg interfere with hydroxyapatite formation triggered by uremia, aging bone abnormalities such as osteoporosis and osteomalacia and other bone abnormalities.
So the correlation between Mg and bone health is linear.
About mortality ;low blood Mg associated with increase risk of death due to heart failure and and coronary A disease even level between 0.7-0.8mmol/L.
Observational studies show that higher blood Mg associated with decrease risk of vascular calcification.
Other studies show blood Mg less than 1.14mmol/l more risk of mortality.
In Japanese studies show U shaped correlation as blood Mg more than 1.27mmol/associated with high cardio-vascular mortality.
Serum Mg2+ concentration and cardiovascular mortality risk are inversely related. In large dialysis patient cohorts, greater serum Mg2+ concentrations were related with lower vascular calcification risk.
Dialysis patients with Mg2+ concentrations <1.14 mmol/L had higher death rates. In other trials, dialysis patients with blood Mg2+ values <1.23 mmol/L, 1.15, and 1.21 had higher cardiovascular and all-cause mortality.
These serum Mg2 values exceed the standard value. Supranormal Mg2+ concentrations may improve CKD survival. Significantly, large Japanese cohort research found a U-shaped curve for this connection, whereby blood Mg2+ concentrations >1.27 mmol/L increased cardiovascular mortality.
These observational studies show that CKD and dialysis patients should maintain blood Mg2 values between 1.14 and 1.27 mmol/L.
#hypomagnesaemia concentration is a well-known risk factor for cardiovascular disease, events and mortality in the patients with higher base-line cardiovascular risk # in patients with dialysis-dependent CKDis associated with an increased risk of death from heart failure and coronary heart disease ###a large Japanese cohort study reports a U-shaped curve for this association, as hypomagnesmia was associated with increased cardiovascular mortality
Do you think the relationship between serum Mg and bone health and mortality is linear or U-shaped? Explain.
Hypomagnesaemia (Mg < 0.7 mmol/l) is a risk factor for cardiovascular disease, events & mortality in those with cardiovascular risk and dialysis patients.
The relationship is a U – shape and not linear.
The is supported by the evidence from a Japanese cohort study; they demonstrated that Mg > 1.27 mmol/l was associated with with increased cardiovascular mortality.
According to this study , Mg in the range of 1.14 to 1.27 mmol/l may be optimal but it has to be individualized
The relationshio between serum magnesium and bone health/mortality is U Shaped. It means too low and too high level can cause mortality and need to aim along certain range as per observational studies on HD patient and large Japanes Cohort Study
The relationship was found as U-shaped, not linear.
The Japanese cohort study showed that higher levels of magnesium (>1.27 mmol/L) could be associated with increased mortality as well.< 0.7 mmol/L is also known to increase cardiovascular mortality.
Observational studies in large groups of dialysis patients reported that a higher serum Mg2þ concentration is associated with a reduced risk of developing vascular calcification .Dialysis patients with a Mg2þ concentration <1.14mmol/L showed significantly more risk for mortality . In other studies, blood Mg2þ concentrations <1.23mmol/L , 1.15mmol/L and 1.21mmol/L were associated with increased cardiovascular and all-cause mortality in dialysis patients. Of note, these concentrations are all above the reference value for serumMg2þ. This suggests that supranormal Mg2þ concentrations beneficially impact survival rate in CKD. Importantly, a large Japanese cohort study reports a U-shaped curve for this association, as a blood Mg2þ concentration >1.27mmol/L was associated with increased cardiovascular mortality. Together, these observational studies suggest that a blood Mg2þ concentration between 1.14 and 1.27mmol/L may be optimal and maintaining blood Mg2þ concentrations in this range in CKD and dialysis patients might be of importance.
Do you think the relationship between serum Mg and bone health and mortality is linear or U-shaped? Explain.
it’s a U shape relation, with hypomagnesemia (<0.7mmol) associated with negative outcome and hypermagnesemia (>1.27 mmol) associated with negative outcome
U shaped
Hypomagnesaemia (serum Mg concentration <0.7mmol/L) is a well-known risk factor for cardiovascular disease, events and mortality in the patients with higher base- line cardiovascular risk and in patients with dialysis-dependent CKD .Besides its blood concentrations, low dietary Mg intake is also associated with all-cause mortality, risk of stroke, heart failure and diabetes mellitus type 2 in the general population .Lower blood Mg concentration is associated with an increased risk of death from heart failure and coronary heart disease, even at concentrations (0.7–0.8 mmol/L) that fall within the reference range for serum Mg ,which is typically between 0.7 and 1.0 mmol/L .
Observational studies in large groups of dialysis patients reported that a higher serum Mg concentration is associated with a reduced risk of developing vascular calcification .Dialysis patients with a Mg concentration <1.14mmol/L showed significantly more risk for mortality .In other studies, blood Mg concentrations <1.23 mmol/L ,1.15 mmol/L and 1.21 mmol/L were associated with increased cardiovascular and all-cause mortality in dialysis patients. Of note, these concentrations are all above the reference value for serum Mg .This suggests that supranormal Mg concentrations beneficially impact survival rate in CKD.
as a blood Mg concentration >1.27 mmol/L was associated with increased cardiovascular mortality , a large Japanese cohort study reports a U-shaped curve for this association.
Together, these observational studies suggest that a blood Mg concentration between 1.14 and 1.27 mmol/L may be optimal and maintaining blood Mg con- centrations in this range in CKD and dialysis patients might be of importance.
So the relationship between serum Mg and bone health and mortality is U-shaped.
Magnesium is important for many processes in the body. It is needed for muscles and nerves to work properly, to keep blood sugar and blood pressure at the right level, and to make protein, bone, and DNA.
hypomagnesemia was associated with increased cardiovascular mortality.
so .
the relationship between serum Mg and bone health and mortality is U-shaped
The relation between bone health and serum mg and mortality is u shaped.
The explanation from a Japanese cohort study; they demonstrated that Mg > 1.27 mmol/l was associated with with increased cardiovascular mortality.
According to this study , Mg in the range of 1.14 to 1.27 mmol/l may be optimal but it has to be individualized so must maintain serum mg with in normal level and avoid hypomagnesemia and hypermagnisima
Income studies, blood Mg concentrations<1.23 mmol/l, 1.15 mmol/L and 1.21 mmol/L were associated with increased cardiovascular and all-cause mortality in dialysis patients.
Of note, these concentrations are all above the reference value for serum Mg. This suggests that supranormal Mg concentrations beneficially impact survival rate in CKD. Importantly, a large Japanese cohort study reports a U-shaped curve for this association, as a blood Mg concentration >1.27 mmol/L was associated with increased cardiovas- ocular mortality.
Together, these observational studies suggest that a blood Mg concentration between 1.14 and 1.27 mmol/L may be optimal and maintaining blood Mg concentrations in this range in CKD and dialysis patients might be of significance.
the relationship is u shaped high Mg level more than 1.27mmol/l was assosciated with hihg mortality while low Mg levels between 1.1-1.27 were optimal, serum Mg less than 0.7 is a well known risk factor of CVS disease
the relationship between serum Mg and bone health and mortality is U-shaped:
Studies have shown that there is an inverse correlation between serum Mg2+ levels and the risk of cardiovascular mortality, particularly among dialysis patients. Low levels of Mg2+ have been associated with higher rates of all-cause and cardiovascular mortality in these patients.
However, some research has suggested that higher than normal levels of Mg2+ could potentially be beneficial for individuals with CKD and undergoing dialysis.
Nonetheless, more research is necessary to establish the optimal range of serum Mg2+ values for these patients. Nevertheless, based on the existing evidence, it is advisable for CKD and dialysis patients to maintain their serum Mg2+ levels within the range of 1.14-1.27 mmol/L.
Bone and Mg
Mortality
Bone considered the body Mg store, because 60%of total body body Mg is in the bone where it is embedded in the surface of the hydroxyapatite crystal.
When there is hypoMagnesemia the hydroxyapatite grow tighter and brittle and less flexible and more prone to fracture.
The Mg increase both osteoblastogenesis and osteoclastogenesis in vitro.
Many studies show that very high level of Blood Mg in late stages CKD patient can affect bone mineralization as Mg interfere with hydroxyapatite formation triggered by uremia, aging bone abnormalities such as osteoporosis and osteomalacia and other bone abnormalities.
So the correlation between Mg and bone health is linear.
About mortality ;low blood Mg associated with increase risk of death due to heart failure and and coronary A disease even level between 0.7-0.8mmol/L.
Observational studies show that higher blood Mg associated with decrease risk of vascular calcification.
Other studies show blood Mg less than 1.14mmol/l more risk of mortality.
In Japanese studies show U shaped correlation as blood Mg more than 1.27mmol/associated with high cardio-vascular mortality.
Serum Mg2+ concentration and cardiovascular mortality risk are inversely related. In large dialysis patient cohorts, greater serum Mg2+ concentrations were related with lower vascular calcification risk.
Dialysis patients with Mg2+ concentrations <1.14 mmol/L had higher death rates. In other trials, dialysis patients with blood Mg2+ values <1.23 mmol/L, 1.15, and 1.21 had higher cardiovascular and all-cause mortality.
These serum Mg2 values exceed the standard value. Supranormal Mg2+ concentrations may improve CKD survival. Significantly, large Japanese cohort research found a U-shaped curve for this connection, whereby blood Mg2+ concentrations >1.27 mmol/L increased cardiovascular mortality.
These observational studies show that CKD and dialysis patients should maintain blood Mg2 values between 1.14 and 1.27 mmol/L.
# hypomagnesaemia concentration is a well-known risk factor for cardiovascular disease, events and mortality in the patients with higher base-line cardiovascular risk
# in patients with dialysis-dependent CKDis associated with an increased risk of death from heart failure and coronary heart disease
###a large Japanese cohort study reports a U-shaped curve for this association,
as hypomagnesmia was associated with increased cardiovascular mortality
Do you think the relationship between serum Mg and bone health and mortality is linear or U-shaped? Explain.