FGF-23-klotho is one of the most extensively studied pathways in CKD. Explain its adaptive and mal-adaptive effects on kidney, heart, and parathyroid glands. Wnt-inhibitors play an important role in the kidney-bone-vascular axis. Highlight the presumed effect of sclerostin, a soluble Wnt-inhibitor, on bone and cardiovascular system. Osteocalcin is a calcium-binding bone-matrix protein produced by osteoblasts. […]
